Complex Profile of Altered Heavy Metals Accumulation in Multiple Sclerosis, a Relationship with Copper and Zinc Homeostasis

BACKGROUND: Multiple sclerosis (MS) is a demyelinating inflammatory disease of the central nervous system white matter. Both environmental and genetic factors have been implicated in its pathogenesis. Heavy metals generate free radicals causing alteration material blood-brain barrier damage. In addition, intracellular accumulation certain heavy can trigger autoimmune reaction against myelin proteins nerves cytoskeletal proteins. AIM: We aimed to analyse complex profile altered multiple relationship with copper zinc homeostasis. METHODS: The present study was carried out period between September 2019 May 2021 on 86 MS Egyptian patients age gender matched healthy controls. Whole blood levels lead (Pb), mercury (Hg), Cadmium (Cd) microgram/liter (μg/L) addition Zinc (Zn) Copper (Cu) milligram/liter (mg/L) were quantitated using Agilent ICP-MS-MS. current also discussed physiological-toxic interactions these patients. RESULTS: demonstrated significant relations toxic suggested by significantly higher Pb, Hg, Cd lower Zn Cu as well Cu/ than Besides, it could be assumed that; physiological homeostasis limits that share absorption transport binding sites, negative correlations whole both Hg Pb. CONCLUSION: A elements rather single element imbalance pathogenesis suggested.